Key result
Severe pediatric OSA is linked to reduced nighttime baroreflex gain and higher left ventricular mass.
Why the study?
Does obstructive sleep apnea impair nighttime baroreflex gain and increase blood pressure variability in children?
Cross-Sectional (n=169)
No
Does obstructive sleep apnea impair nighttime baroreflex gain and increase blood pressure variability in children?
p-value: p=<0.0001
The study demonstrates that pediatric obstructive sleep apnea is associated with impaired cardiovascular autonomic control and increased blood pressure variability, which correlates with early signs of left ventricular remodeling.
Severe pediatric OSA links to baroreflex impairment and LV remodeling; hypothesis-generating and should not yet change practice.
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McConnell et al. (2009) conducted a cross-sectional in Obstructive sleep apnea (n=169). Obstructive sleep apnea vs. Healthy control subjects without obstructive sleep apnea was evaluated on Nighttime baroreflex gain and left ventricular mass index (p=<0.0001). Children with severe obstructive sleep apnea have significantly decreased nighttime baroreflex gain (p<0.0001) and increased blood pressure variability compared to healthy controls, correlating with increased left ventricular mass index.
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