Configurational control of low-symmetry heteroleptic metal–organic cages with asymmetric ligands

to undergo a structural transformation and selectively assemble into a single dominant configuration from 13 potential isomers. This work not only demonstrates the immense potential of integrating asymmetric ligand assembly with multi-ligand co-assembly strategies but also highlights the critical role of steric effects in guiding assembly pathways and achieving precise configurational control in low-symmetry MOCs.