Key result
Chronic alcohol exposure exacerbated bilateral ischemia-reperfusion-induced renal fibrosis and renal function impairment in mice via β-arrestin 2 and GSK3β-mediated signaling.
Why the study?
Does chronic alcohol exposure exacerbate renal fibrosis and function impairment in mice with ischemia-reperfusion-induced acute kidney injury?
Population
Mice (wild-type and Arrb2-/-) subjected to bilateral renal ischemia-reperfusion injury (15 minutes clamping)
Comparison
Alcohol-rich diet for two weeks vs Normal diet
Design
Preclinical
Follow-up
two weeks
Authors
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May warrant alcohol caution in AKI recovery; hypothesis-generating in animals, needs human validation.
Does chronic alcohol exposure exacerbate renal fibrosis and function impairment in mice with ischemia-reperfusion-induced acute kidney injury?
p-value: p=<0.05
Chronic alcohol exposure exacerbates ischemia-reperfusion-induced acute kidney injury and renal fibrosis in mice via the β-arrestin 2/Akt/GSK3β signaling pathway.
Wang et al. (2017) studied Ischemia-reperfusion-induced acute kidney injury. Chronic alcohol exposure vs. Dextrose-containing liquid diet was evaluated on Renal fibrosis and renal function impairment (BUN and creatinine levels) at 14 days post ischemia-reperfusion (p=<0.05). Chronic alcohol exposure exacerbated bilateral ischemia-reperfusion-induced renal fibrosis and renal function impairment in mice via β-arrestin 2 and GSK3β-mediated signaling.
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