DNA damage to human genetic disorders with neurodevelopmental defects

for MMR) for their research into mapping the mechanisms that underlie DNA damage repair at a detailed molecular level. On the other hand, DNA strand breaks could happen to one or both strands. Organisms have developed sophisticated mechanisms to deal with either DNA single strand breaks (SSBs) or DNA double strand breaks (DSBs) DNA DSB repair mechanisms are further divided into 2 major distinct pathways: homologous recombination repair (HRR) and non-DNA damage to human genetic disorders with neurodevelopmental defects