Key result
Degradation of high molecular weight multimers of von Willebrand factor increased significantly with higher Reynolds number (p<0.0001) and exposure time (p=0.0034) in an in vitro high-shear model.
Why the study?
Loss of high molecular weight multimers of von Willebrand factor in aortic stenosis and continuous-flow LVADs is linked to high turbulent shear, but degradation mechanisms regarding exposure time and flow regime are not well understood.
p-value: p=<0.0001
In an in vitro model, both flow regime (Reynolds number) and exposure time significantly contribute to the degradation of high molecular weight multimers of von Willebrand factor, which is relevant to bleeding complications in aortic stenosis and LVADs.
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Informs high-shear device engineering to limit vWF degradation; leaves open clinical bleeding relevance pending in vivo data.
Jhun et al. (2022) studied Aortic stenosis and continuous-flow left ventricular assist devices (context). High turbulent blood shear (Reynolds number and exposure time) vs. Laminar flow was evaluated on Degradation of high molecular weight multimers (HMWM) of von Willebrand factor (p=<0.0001). Degradation of high molecular weight multimers of von Willebrand factor increased significantly with higher Reynolds number (p<0.0001) and exposure time (p=0.0034) in an in vitro high-shear model.
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