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March 27, 2020Journal of Medicinal ChemistryOpen Access

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo

Zhiqiang Li Xinzhi Li Mingbo Su Lixin Gao Yubo Zhou Bingchuan Yuan Xilin Lyu Ziqin Yan Chujiao Hu Hao Zhang Cheng Luo Zheng Chen Jia Li Yujun Zhao

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Abstract

also decreased immune cell infiltration into the injured liver tissue. Overall, these studies provide examples that an NIK inhibitor is able to suppress toxin-induced liver inflammations, which indicates its therapeutic potentials for the treatment of liver inflammatory diseases.

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Li et al. (2020) studied this question.

synapsesocial.com/papers/6a5e255151b6d15671709245 https://doi.org/10.1021/acs.jmedchem.0c00396

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