Intramyocardial injection of FR/drugMAP enhanced left ventricular functions, increased angiogenesis, and reduced fibrosis and inflammatory response compared to MAP gel in a rat model of MI.
Does intramyocardial injection of FR/drugMAP improve left ventricular function and reduce adverse remodeling in a rat model of myocardial infarction?
A novel injectable drug-releasing microporous hydrogel system loaded with forskolin and Repsox improves cardiac function and reduces adverse remodeling in a rat model of myocardial infarction.
Intramyocardial injection of hydrogels offers great potential for treating myocardial infarction (MI) in a minimally invasive manner. However, traditional bulk hydrogels generally lack microporous structures to support rapid tissue ingrowth and biochemical signals to prevent fibrotic remodeling toward heart failure. To address such challenges, a novel drug-releasing microporous annealed particle (drugMAP) system is developed by encapsulating hydrophobic drug-loaded nanoparticles into microgel building blocks via microfluidic manufacturing. By modulating nanoparticle hydrophilicity and pregel solution viscosity, drugMAP building blocks are generated with consistent and homogeneous encapsulation of nanoparticles. In addition, the complementary effects of forskolin (F) and Repsox (R) on the functional modulations of cardiomyocytes, fibroblasts, and endothelial cells in vitro are demonstrated. After that, both hydrophobic drugs (F and R) are loaded into drugMAP to generate FR/drugMAP for MI therapy in a rat model. The intramyocardial injection of MAP gel improves left ventricular functions, which are further enhanced by FR/drugMAP treatment with increased angiogenesis and reduced fibrosis and inflammatory response. This drugMAP platform represents a new generation of microgel particles for MI therapy and will have broad applications in regenerative medicine and disease therapy.
Fang et al. (Sun,) conducted a other in Myocardial infarction. FR/drugMAP (forskolin and Repsox loaded drug-releasing microporous annealed particle system) vs. MAP gel was evaluated on Left ventricular functions, angiogenesis, fibrosis, and inflammatory response. Intramyocardial injection of FR/drugMAP enhanced left ventricular functions, increased angiogenesis, and reduced fibrosis and inflammatory response compared to MAP gel in a rat model of MI.