Key result
Highest plasma BNP levels (≥ 39.2 ng/mL) were independently associated with increased odds of microalbuminuria (OR 2.61) and macroalbuminuria (OR 3.45) in Japanese patients with type 2 diabetes.
Why the study?
Is elevated B-type natriuretic peptide associated with renal dysfunction in Japanese patients with type 2 diabetes mellitus?
Cross-Sectional (n=687)
Yes
Is elevated B-type natriuretic peptide associated with renal dysfunction in Japanese patients with type 2 diabetes mellitus?
, 3) microalbuminuria: urinary albumin creatinine ratio (UACR) ≥ 30 mg/g creatinine, and 4) macroalbuminuria: UACR ≥ 300 mg/g creatinine. The prevalence values of CKD, advanced CKD, microalbuminuria, and macroalbuminuria were 27.4％, 2.5%, 31.4%, and 9.3%, respectively. Highest BNP (≥ 39.2 ng/ml) was independently positively associated with microalbuminuria and macroalbuminuria (adjusted ORs, 2.61 [95% CI: 1.53-4.49] and 3.45 [95% CI: 1.46-8.72], respectively). High BNP was not associated with advanced CKD or CKD. There was a statistically significant positive exposure-response relationships between the BNP level and advanced CKD, microalbuminuria, and macroalbuminuria (p for trend = 0.047, 0.001, and 0.003, respectively). BNP level may be independently positively associated with advanced CKD, microalbuminuria, and macroalbuminuria but not CKD in Japanese patients with type 2 diabetes mellitus.
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Furukawa et al. (2017) conducted a cross-sectional in Type 2 diabetes mellitus (n=687). High plasma B-type natriuretic peptide (BNP ≥ 39.2 ng/mL) vs. Low plasma BNP (< 9.9 ng/mL) was evaluated on Microalbuminuria (UACR ≥ 30 mg/g creatinine) (OR 2.61, 95% CI 1.53-4.49, p=0.001). Highest plasma BNP levels (≥ 39.2 ng/mL) were independently associated with increased odds of microalbuminuria (OR 2.61) and macroalbuminuria (OR 3.45) in Japanese patients with type 2 diabetes.
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