Key result
In a mouse model of ischemia-reperfusion, the area of microvascular leakage (75 ± 2%) was significantly greater than that of infarction (47 ± 4%, P < 0.01) or microvascular obstruction.
Population
Mouse ischemia-reperfusion (I/R) model
Design
Preclinical
Follow-up
up to 24-48 h after reperfusion
Authors
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Supports CMR-LGE quantification of microvascular leakage in preclinical models; leaves open clinical translation and therapeutic targeting.
Absolute Event Rate: 75% vs 47%
p-value: p=< 0.01
Microvascular leakage following ischemia-reperfusion injury affects a larger myocardial area than infarction or microvascular obstruction and can be accurately characterized using CMR-LGE.
Gao et al. (2017) studied Acute myocardial infarction / ischemia-reperfusion injury. Ischemia-reperfusion (I/R) vs. Infarction or microvascular obstruction (MVO) was evaluated on Area of microvascular leakage (MVL) vs infarct within the risk zone (p=< 0.01). In a mouse model of ischemia-reperfusion, the area of microvascular leakage (75 ± 2%) was significantly greater than that of infarction (47 ± 4%, P < 0.01) or microvascular obstruction.
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