Key result
This review outlines the clinical manifestations, preventive strategies, and pharmaceutical management of cardiotoxicity in patients with hematologic malignancies undergoing anticancer therapy.
Why the study?
Anticancer therapies for hematological malignancies can cause cardiovascular complications that jeopardize improved oncologic outcomes, requiring familiarity with cardiotoxicity and prompt, appropriate management.
This review highlights the importance of recognizing and managing cardiotoxicity in patients with hematological malignancies to preserve the benefits of modern anticancer therapies.
May raise awareness of cardiotoxicity monitoring in hematological malignancy care; leaves open need for prospective trials to guide protocols.
Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies. Nevertheless, many new or conventional anticancer drugs affect the cardiovascular system, resulting in various cardiac disorders, including left ventricular dysfunction, heart failure, arterial hypertension, myocardial ischemia, cardiac rhythm disturbances, and QTc prolongation on electrocardiograms. As these complications may jeopardize the significantly improved outcome of modern anticancer therapies, it is crucial to become familiar with all aspects of cardiotoxicity and provide appropriate care promptly to these patients. In addition, established and new drugs contribute to primary and secondary cardiovascular diseases prevention. This review focuses on the clinical manifestations, preventive strategies, and pharmaceutical management of cardiotoxicity in patients with hematologic malignancies undergoing anticancer drug therapy or hematopoietic stem cell transplantation.
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Perpinia et al. (2022) conducted a review in Cardiotoxicity in hematological malignancies. Pharmaceutical prevention and management was evaluated. This review outlines the clinical manifestations, preventive strategies, and pharmaceutical management of cardiotoxicity in patients with hematologic malignancies undergoing anticancer therapy.
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