Key points are not available for this paper at this time.
Rationale: It has been reported that peroxisome proliferator activated receptor (PPAR) level decreases significantly in the brains of Alzheimer's disease (AD) patients and mice models, while the mechanism is unclear. This study aims to unravel the mechanism that amyloid (A) decreases PPAR and attempted to discover lead compound that preserves PPAR.
Zhang et al. (Mon,) studied this question.