Key result
Cortisol infusion in fetal sheep increased the proportion of left ventricular cardiomyocytes in the cell cycle (5.5% vs 2.7%, P<0.005) and increased heart weight.
Why the study?
Does cortisol infusion stimulate cardiomyocyte proliferation or terminal differentiation in near-term fetal sheep?
Does cortisol infusion stimulate cardiomyocyte proliferation or terminal differentiation in near-term fetal sheep?
Absolute Event Rate: 5.5% vs 2.7%
p-value: p=<0.005
Subpressor doses of cortisol stimulate cardiomyocyte proliferation rather than hypertrophic growth in the fetal sheep heart.
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Should not alter fetal cardiac care; leaves open glucocorticoid effects on human cardiomyocyte proliferation.
Giraud et al. (2006) studied Fetal cardiomyocyte growth (n=22). Cortisol vs. Control was evaluated on Proportion of left ventricular myocytes staining for Ki-67 (p=<0.005). Cortisol infusion in fetal sheep increased the proportion of left ventricular cardiomyocytes in the cell cycle (5.5% vs 2.7%, P<0.005) and increased heart weight.
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