Key result
Nanoparticles show therapeutic and diagnostic promise for targeting cardiac remodeling and regeneration.
Why the study?
Cardiovascular diseases remain the leading cause of death globally, and advances in nanomedicine for controlled drug delivery may offer substantial contributions to cardiac remodeling and regeneration.
This review highlights the emerging potential of nanomedicine in targeting cardiac remodeling and regeneration pathways, offering novel therapeutic and diagnostic strategies for ischemic heart disease.
Nanoparticle strategies for cardiac remodeling remain investigational; supports further research but leaves open clinical translation pending trials.
Cardiovascular diseases are the main cause of death worldwide, a trend that will continue to grow over the next decade. The heart consists of a complex cellular network based mainly on cardiomyocytes, but also on endothelial cells, smooth muscle cells, fibroblasts, and pericytes, which closely communicate through paracrine factors and direct contact. These interactions serve as valuable targets in understanding the phenomenon of heart remodeling and regeneration. The advances in nanomedicine in the controlled delivery of active pharmacological agents are remarkable and may provide substantial contribution to the treatment of heart diseases. This review aims to summarize the main mechanisms involved in cardiac remodeling and regeneration and how they have been applied in nanomedicine.
No takes yet. Share an insight, caveat, or question.
Gonciar et al. (2022) conducted a review in Cardiovascular diseases, heart remodeling and regeneration. Nanoparticles was evaluated. Nanoparticles targeting molecular pathways of heart remodeling and regeneration offer promising therapeutic and diagnostic strategies for cardiovascular diseases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: