Key result
Positive expression of the angiotensin II type 1 receptor in ovarian cancer tissues was significantly associated with poorer overall survival (P=0.041) compared to negative expression.
Why the study?
Does AT1R expression correlate with tumour angiogenesis and patient survival in ovarian cancer?
Cohort (n=67)
No
Does AT1R expression correlate with tumour angiogenesis and patient survival in ovarian cancer?
p-value: p=0.041
AT1R expression correlates with tumour angiogenesis and poor patient outcome in ovarian cancer, suggesting it may be a potential therapeutic target.
Authors
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AT1R expression signals higher angiogenesis and poorer survival in ovarian cancer; leaves open whether blockade improves outcomes.
Ino et al. (2006) conducted a cohort in Ovarian cancer (n=67). Positive AT1R expression vs. Negative AT1R expression was evaluated on Overall survival (p=0.041). Positive expression of the angiotensin II type 1 receptor in ovarian cancer tissues was significantly associated with poorer overall survival (P=0.041) compared to negative expression.
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