Key result
PLC stimulation triggers NCX-mediated Ca2+ entry dependent on TRPC3-mediated Na+ loading, suggesting a TRPC3-NCX1 complex controls cardiac Ca2+ homeostasis.
Population
Rat cardiac myocytes
Design
Preclinical
Authors
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TRPC3-NCX1 complex mediates PLC-driven Ca2+ entry in myocytes; leaves open its therapeutic targeting in human cardiac disease.
Demonstrates a physical and functional coupling of TRPC3 and NCX1 in rat cardiac myocytes, suggesting their complex is pivotal for PLC-dependent cardiac calcium homeostasis.
Eder et al. (2006) studied Cardiac Ca2+ homeostasis. Dominant negative knockdown of TRPC3 was evaluated on Protein expression, cellular distribution, protein-protein interactions, and calcium signals. PLC stimulation triggers NCX-mediated Ca2+ entry dependent on TRPC3-mediated Na+ loading, suggesting a TRPC3-NCX1 complex controls cardiac Ca2+ homeostasis.
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