ZEBs: Novel Players in Immune Cell Development and Function

ZEB proteins are expressed by various immune cells, where they can mediate the differentiation, maintenance, and function of these cells. ZEB2 can regulate terminal differentiation in murine lymphocytes via a regulatory program that includes T-bet and ID2. ZEB2 is required by murine plasmacytoid DCs (pDCs), tissue-resident macrophages, and monocytes for their development and/or survival; in pDCs, ZEB2 represses ID2 activity. The precise role for ZEB2 in conventional dendritic cells type 2 (cDC2s) remains unclear because deletion of ZEB2 has only a minor effect on murine cDC2 numbers. ZEB1 can regulate cytokine expression from cDC1s upon activation with CpG. ZEB1 and ZEB2 can play reciprocal roles in CD8+ T cells. 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