Key result
In stable patients with end-stage renal disease, combined high levels of cTnT and CRP were associated with an increased risk of all-cause mortality compared to low levels (HR 2.5; 95% CI 1.5-4.0).
Why the study?
Do elevated levels of cTnT and CRP predict all-cause mortality and cardiac pathology in stable patients with ESRD on long-term hemodialysis?
Population
224 stable patients with end-stage renal disease undergoing long-term hemodialysis without ischemic…
Comparison
Elevated baseline levels of cardiac troponin T… vs Lowest quartile or below median levels of cTnT…
Design
Cohort
Follow-up
mean 827 days (range, 29-1327 days)
Authors
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May aid risk stratification in stable hemodialysis patients; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=224)
Yes
Do elevated levels of cTnT and CRP predict all-cause mortality and cardiac pathology in stable patients with ESRD on long-term hemodialysis?
Hazard Ratio: 2.5 (95% CI 1.5–4)
In stable ESRD patients on hemodialysis, elevated baseline cTnT and CRP are independent predictors of long-term all-cause mortality, with cTnT also indicating severe coronary artery disease.
Christopher R. deFilippi (2003) conducted a cohort in End-stage renal disease (ESRD) (n=224). Elevated cardiac troponin T (cTnT) and C-reactive protein (CRP) vs. Low levels of cTnT and CRP was evaluated on All-cause mortality (HR 2.5, 95% CI 1.5-4.0). In stable patients with end-stage renal disease, combined high levels of cTnT and CRP were associated with an increased risk of all-cause mortality compared to low levels (HR 2.5; 95% CI 1.5-4.0).
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