Key result
Nifedipine GITS 20 mg/telmisartan 80 mg combination significantly reduced ambulatory blood pressure and achieved earlier control compared to single monotherapies at 8 weeks.
Why the study?
Does nifedipine 20 mg/telmisartan 80 mg combination reduce ambulatory blood pressure in high-risk hypertensive patients compared to monotherapy?
RCT (n=400)
Does nifedipine 20 mg/telmisartan 80 mg combination reduce ambulatory blood pressure in high-risk hypertensive patients compared to monotherapy?
Combination therapy with nifedipine GITS 20 mg and telmisartan 80 mg provides superior blood pressure reduction and a better side-effect profile compared to monotherapy in high-risk hypertensive patients.
May support combo over monotherapy for BP control in high-risk hypertension; hypothesis-generating, needs RCT confirmation.
Current guidelines on antihypertensive treatment emphasize the importance of combination drug treatment for achieving a full blood pressure control. The TALENT Study, involving more than 400 high-risk hypertensive patients, aimed to evaluate the efficacy and safety profile of nifedipine gastrointestinal therapeutic system (GITS) 20 mg/telmisartan 80 mg combination, as compared to the single monotherapies. After 8 weeks, ambulatory blood pressure values were significantly more reduced by the combination treatment than by single monotherapies. These potentiated blood-pressure-lowering effects were mirrored by a higher trough-to-peak ratio and smoothness index. They were also accompanied by: i) significantly greater blood pressure (particularly systolic) control; ii) a greater ability of combination drug treatment to achieve a controlled blood pressure at a time earlier than that found in single monotherapies; and iii) a better side-effects profile.
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Guıdo Grassı (2012) conducted an RCT in High-risk hypertension (n=400). Nifedipine GITS/telmisartan combination vs. Single monotherapies was evaluated on Ambulatory blood pressure values. Nifedipine GITS 20 mg/telmisartan 80 mg combination significantly reduced ambulatory blood pressure and achieved earlier control compared to single monotherapies at 8 weeks.
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