Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis

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The alginate oligosaccharide AOS3 ameliorates joint pain and inflammation in gouty arthritis by activating Nrf2-dependent antioxidant signaling, which suppresses ROS-mediated NLRP3 inflammasome activation and TRPV1 enhancement. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Chengyu Yin; Qianqian Lyu; Zishan Dong; Boyu Liu; Keke Zhang; Zhende Liu; Qìng Yu; Peiyi Li; Zhuoqun Wei; Yan Tai; Chuan Wang; Jianqiao Fang; Weizhi Liu; Boyi Liu

doi:10.7150/thno.95611

January 1, 2024TheranosticsOpen Access

Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis

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Abstract

AOS3 ameliorates gouty arthritis via activating Nrf2-dependent antioxidant signaling, resulting in suppression of ROS-mediated NLRP3 inflammasome activation and TRPV1 enhancement. AOS3 may be novel therapeutics for gouty arthritis.

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Yin et al. (2024) studied this question.

synapsesocial.com/papers/6a5eb982531077db68af0154 https://doi.org/10.7150/thno.95611

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Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis

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Well-defined alginate oligosaccharides ameliorate joint pain and inflammation in a mouse model of gouty arthritis

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