Key result
Hydrogen sulfide supplementation ameliorated pathological remodeling and dysfunction post-MI in mice, resulting in decreased infarct size and mortality via promotion of M2 macrophage polarization.
Why the study?
Does hydrogen sulfide supplementation improve cardiac remodeling and reduce infarct size and mortality in mouse models of myocardial infarction?
Does hydrogen sulfide supplementation improve cardiac remodeling and reduce infarct size and mortality in mouse models of myocardial infarction?
Hydrogen sulfide exerts cardioprotective effects post-myocardial infarction by promoting mitochondrial biogenesis-dependent M2 polarization of macrophages.
May open adjunctive post-MI options via M2 polarization; extends preclinical redox targets for macrophage-mediated repair.
AIMS: Macrophages are of key importance for tissue repair after myocardial infarction (MI). Hydrogen sulfide (H2S) has been shown to exert cardioprotective effects in MI. However, the mechanisms by which H2S modulates cardiac remodeling and repair post-MI remain to be clarified. RESULTS: In our current study, we showed that H2S supplementation ameliorated pathological remodeling and dysfunction post-MI in wild-type (WT) and CSE KO mice, resulting in decreased infarct size and mortality, accompanied by an increase in the number of M2-polarized macrophages at the early stage of MI. Strikingly, adoptive transfer of NaHS-treated bone marrow-derived macrophages into WT and CSE KO mice with depleted macrophages also ameliorated MI-induced cardiac functional deterioration. Further mechanistic studies demonstrated that NaHS-induced M2 polarization was achieved by enhanced mitochondrial biogenesis and fatty acid oxidation. INNOVATION AND CONCLUSION: Our study shows (for the first time) that H2S may have the potential as a therapeutic agent for MI via promotion of M2 macrophage polarization. Rebound Track: This work was rejected during standard peer review and rescued by Rebound Peer Review (Antioxid Redox Signal 16:293-296, 2012) with the following serving as open reviewers: Hideo Kimura, Chaoshu Tang, Xiaoli Tian, and Kenneth Olson. Antioxid. Redox Signal. 25, 268-281.
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Miao et al. (2016) studied Myocardial infarction. Hydrogen sulfide (H2S) / NaHS was evaluated on Pathological remodeling, dysfunction, infarct size, and mortality post-MI. Hydrogen sulfide supplementation ameliorated pathological remodeling and dysfunction post-MI in mice, resulting in decreased infarct size and mortality via promotion of M2 macrophage polarization.
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