Key result
Hyperlipidemic pancreatitis was associated with a significantly higher rate of LPL gene mutations compared to hypertriglyceridemia without pancreatitis (17.0% vs 4.9%, P<0.0001).
Why the study?
Are LPL and apo CII gene mutations associated with acute and chronic pancreatitis in patients with hypertriglyceridemia?
Population
134 patients in Taiwan with hypertriglyceridemia, including 53 with hyperlipidemic pancreatitis and 81…
Comparison
Presence of LPL and apo CII gene mutations vs Absence of LPL and apo CII gene mutations
Design
Cohort
Authors
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Genetic testing for LPL/apo CII variants may refine pancreatitis risk stratification in HTG; leaves open need for prospective validation before clinical use.
Observational (n=134)
Are LPL and apo CII gene mutations associated with acute and chronic pancreatitis in patients with hypertriglyceridemia?
Absolute Event Rate: 17% vs 4.9%
p-value: p=<0.0001
The LPL S447X mutation is associated with a significantly higher risk of hyperlipidemic pancreatitis attacks, pancreatic calcification, and steatorrhea in patients with hypertriglyceridemia.
Chang et al. (2009) conducted an observational in Hypertriglyceridemia and hyperlipidemic pancreatitis (n=134). Hyperlipidemic pancreatitis (HLP) vs. Hypertriglyceridemia without HLP was evaluated on LPL gene mutation rate (p=<0.0001). Hyperlipidemic pancreatitis was associated with a significantly higher rate of LPL gene mutations compared to hypertriglyceridemia without pancreatitis (17.0% vs 4.9%, P<0.0001).