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This research aims to evaluate the immunogenicity and efficacy of DNA vaccines targeting DEC205 antigens against influenza A virus.

March 27, 2015ImmunologyOpen Access

DNA vaccines encoding DEC205‐targeted antigens: immunity or tolerance?

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This research aims to evaluate the immunogenicity and efficacy of DNA vaccines targeting DEC205 antigens against influenza A virus.
Utilized electroporation to deliver dendritic cell-targeted DNA vaccines to wild-type BALB/c mice.
Conducted adoptive transfer experiments to track antigen-specific T cell responses post-vaccination.
Compared immune responses between DNA encoding DEC205-targeted and non-targeted antigens.
T-cell responses in mice vaccinated with DEC205-targeted DNA vaccines were significantly reduced compared to non-targeted ones.
These mice showed a local expansion of regulatory T cells, which hindered the activation of effector T cells.
Vaccination with DEC205-targeted antigens induced peripheral tolerance, leading to diminished protection against IAV infection.

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Randomized trial explores immune responses in mice vaccinated with DEC205-targeted DNA vaccines, suggesting tolerance.

Niezold et al. (2015) studied this question.

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