Bioactivity and Element Composition of Three Endodontic Root Canal Sealers

BACKGROUND: This study aimed to evaluate the bioactivity and depth of penetration of three endodontic root canal sealers: AH Plus (AH), Endosequence Bioceramic Sealer BC, and Endosequence Bioceramic HiFlow Sealer (HiFlow). MATERIALS AND Hydroxyapatite crystal formation was observed in PBS-immersed samples from the HiFlow sealer group, indicating the bioactivity of bioceramic sealers. CONCLUSION: All three sealers show some form of bioactivity represented by the release of different elements. HiFlow demonstrated superior penetration depth, particularly when used with WVC. CLINICAL SIGNIFICANCE: Based on the results of the study, the use of HiFlow root canal sealer combined with WVC results in better sealer-dentin interaction and improves the quality of obturation. How to cite this article: Alsofi L. Bioactivity and Element Composition of Three Endodontic Root Canal Sealers. J Contemp Dent Pract 2025;26(1):62-70.