Key result
Pre-treatment with docetaxel 12 hours before adriamycin administration significantly reduced adriamycin-induced toxic death and cardiotoxicity in mice.
Why the study?
Does pre-treatment with docetaxel reduce adriamycin-induced cardiotoxicity and toxic death in a preclinical model?
Does pre-treatment with docetaxel reduce adriamycin-induced cardiotoxicity and toxic death in a preclinical model?
p-value: p=<0.05
Docetaxel pre-administration 12 hours before adriamycin reduces cardiotoxicity and toxic death by inhibiting free radical generation (lipid peroxidation) without altering adriamycin pharmacokinetics.
DOC pre-treatment may reduce ADR cardiotoxicity; leaves open clinical translation and optimal scheduling.
We revealed that pre-treatment with docetaxel (DOC) 12 h before adriamycin (ADR) administration significantly reduced ADR-induced toxic death compared with the simultaneous dosing schedule that was commonly used in previous studies. We considered that pre-treatment with DOC relieves ADR-induced cardiotoxicity. In this study, we investigated the influence of DOC on the pharmacokinetics and pharmacodynamics of ADR in order to clarify the mechanism by which DOC pre-treatment relieves ADR-induced cardiotoxicity. When ADR and/or DOC was intravenously administered, the DOC pre-treatment (DOC-ADR) group showed significantly less toxic death than the ADR-alone group. We examined hepatopathy, nephropathy, leukopenia, and cardiotoxicity, all of which can cause toxic death. Of these toxicities, ADR-induced cardiotoxicity was significantly relieved in the DOC-ADR group. To elucidate the mechanism by which DOC pre-treatment relieved ADR-induced cardiotoxicity, lipid peroxidation as a proxy for the free radical level and the pharmacokinetics of ADR were measured. There was no difference in the pharmacokinetics of ADR between the ADR and DOC-ADR groups. On the other hand, the DOC-ADR group showed significantly inhibited lipid peroxidation in the heart compared with the ADR group. It was considered that DOC pre-administration inhibited ADR-induced free radicals and decreased cardiotoxicity.
No takes yet. Share an insight, caveat, or question.
Tomonari et al. (2011) studied Adriamycin-induced cardiotoxicity. Docetaxel pre-administration vs. Adriamycin alone was evaluated on Survival rate (p=<0.05). Pre-treatment with docetaxel 12 hours before adriamycin administration significantly reduced adriamycin-induced toxic death and cardiotoxicity in mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: