Self-Sustaining Catalytic–Immunological Cycle Powered by a Tumor Microenvironment-Engineered Iridium–MnO ₂ Nanozyme for Photodynamic Immunotherapy

P P Wang; Ying-Ying Han; Qing‐Hua Shen; Z Y Li; Long‐Bo Yu; Cai‐Ping Tan

doi:10.1021/acs.jmedchem.6c01509

July 18, 2026Journal of Medicinal Chemistry

Self-Sustaining Catalytic–Immunological Cycle Powered by a Tumor Microenvironment-Engineered Iridium–MnO ₂ Nanozyme for Photodynamic Immunotherapy

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Key Points

This research aims to develop a self-reinforcing cycle that alleviates hypoxia and activates immunity within tumors.
Engineered iridium–MnO2 nanozyme used for photodynamic therapy (PDT) in tumor models.
Assessment of hypoxia levels and immune response enhancement via in vivo experiments.
Evaluation of treatment efficacy against tumor resistance.
The catalytic system significantly reduced hypoxia levels in the tumor microenvironment.
Immunosuppression was reversed, leading to enhanced antitumor immunity.
The approach showed marked improvement in the effectiveness of PDT compared to traditional methods.

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Implication

Demonstrates improved immune activation and hypoxia relief in tumor microenvironments, suggesting enhanced therapeutic efficacy.

Abstract

, the system relieves hypoxia and reverses immunosuppression. Overall, this work introduces an innovative nanoplatform that establishes a self-reinforcing cycle of hypoxia alleviation and immune activation, offering a potent combinatorial strategy to surmount PDT resistance and amplify antitumor immunity.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a5f0b9186a4235cc16192c4 https://doi.org/10.1021/acs.jmedchem.6c01509

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Self-Sustaining Catalytic–Immunological Cycle Powered by a Tumor Microenvironment-Engineered Iridium–MnO ₂ Nanozyme for Photodynamic Immunotherapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Self-Sustaining Catalytic–Immunological Cycle Powered by a Tumor Microenvironment-Engineered Iridium–MnO ₂ Nanozyme for Photodynamic Immunotherapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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