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July 18, 2026

Sub-chronic exposure to lanthanum chloride induces hepatic steatosis via AMPK-dependent lipophagic defects in male zebrafish.

Xinying Zhao Xiangrong Zhou Keying Li Qiuchen Wu 沙玉芹 Zhuoyi Xie Ping Zeng Zhipeng Qi Qiao Niu Wei Li Weiyi Song

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Key Points

Investigate the effects of lanthanum chloride on liver health in zebrafish, focusing on lipid storage and degradation.
Sub-chronic exposure to lanthanum chloride in male zebrafish
Assessment of hepatic lipid levels and AMPK activity
Analysis of lipophagic processes affected by treatment
Exposure to lanthanum chloride led to significant hepatic steatosis in zebrafish
Disruption of lipid homeostasis correlated with impaired AMPK signaling
Findings suggest potential hepatotoxic effects from environmental exposure to rare earth elements.

Implication

Explores hepatic steatosis in zebrafish, indicating environmental risks from lanthanum chloride exposure.

Abstract

-disrupted hepatic lipid homeostasis, offering novel insights into REEs-related hepatotoxicity and supporting environmental health risk assessment.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a5f0c1886a4235cc1619909 https://doi.org/10.1016/j.ecoenv.2026.120526

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Keep reading

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