The work I wish to present to you had its origin in a chance observation by Claude Bernard (1877) He noticed ,that when starving dogs were allowed to satisfy their hunger with carbohydrate food sugar appeared in their urine. This phenomenon was amply confirmed by suLbsequent workers, but little further progress was made towards understanding its significance until the invention of reliable methods for estimating the blood sugar enabled Bang (1913) to demonstrate that starvation impaired the blood glucose-tolerance curve. Ten years later Adlersberg and Porges (1926, 1929) in Vienna and Sweeney (1927) in America, and soon many other workers, showed that diets rich in fat were associated with a similar impairment of the glucose-tolerance curve and, further, that diets rich in carbohydrates resulted in an improvement of the toler- ance curve. This sudden renewal of interest in the effect of diet upon sugar tolerance was directly attributable to a revolution that had occurred in the therapeutics of diabetes mellitus.
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H. P. Himsworth (1940) studied this question.