Supramolecular Peptide Amphiphile Vesicles through Host–Guest Complexation

Tricky triggering: Supramolecular peptide amphiphiles were prepared by host–guest complexation of pyrene-labeled peptides and viologen lipid with cucurbit8uril. They self-assemble into vesicles, which are responsive to a variety of external triggers. Both “switching on” and “switching off” of fluoresence and cytotoxicity is demonstrated in vitro.