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May 10, 2003Journal of the American Chemical Society135 citations

Total Synthesis of the Duocarmycins

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KYKen YamadaTKToshiki KurokawaHTHidetoshi Tokuyama

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Abstract

The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones.

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Cite This Study

Yamada et al. (2003) studied this question.

synapsesocial.com/papers/6a5f1d4a12cfc71cd8592b0fhttps://doi.org/10.1021/ja035303i
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