November 25, 2014Angewandte Chemie International Edition136 citations
View Full PaperRemote meta‐CH Olefination of Phenylacetic Acids Directed by a Versatile U‐Shaped Template
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Abstract
meta-C-H olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile-containing template. The identification of N-formyl-protected glycine as the ligand (Formyl-Gly-OH) was crucial for the development of this reaction. Versatility of the template approach in accommodating macrocyclopalladation processes with different ring sizes is demonstrated.