Key result
Low transcutaneous oxygen tension (≤ 46 mmHg) was a significant predictor of major adverse cardiovascular events in patients with uncomplicated type 2 diabetes (HR 1.78; 95% CI 1.44-2.23; P<0.001).
Why the study?
Does low transcutaneous oxygen tension (TcPO2) predict major adverse cardiovascular events (MACE) better than ankle brachial index (ABI) in patients with uncomplicated type 2 diabetes?
Population
361 consecutive patients with apparently uncomplicated type 2 diabetes
Comparison
Transcutaneous oxygen tension (TcPO2) measurement vs Ankle brachial index (ABI) measurement
Design
Cohort
Follow-up
45.8 ± 23.2 months
Authors
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TcPO2 may refine MACE risk stratification in diabetes beyond ABI; hypothesis-generating for prospective trials before practice change.
Cohort (n=361)
Does low transcutaneous oxygen tension (TcPO2) predict major adverse cardiovascular events (MACE) better than ankle brachial index (ABI) in patients with uncomplicated type 2 diabetes?
Hazard Ratio: 1.78 (95% CI 1.44–2.23)
p-value: p=< 0.001
Transcutaneous oxygen tension (TcPO2) is a stronger predictor of major adverse cardiovascular events than ankle brachial index (ABI) in patients with uncomplicated type 2 diabetes.
Gazzaruso et al. (2013) conducted a cohort in Type 2 diabetes (n=361). Low transcutaneous oxygen tension (TcPO2 ≤ 46 mmHg) vs. Normal TcPO2 was evaluated on Major adverse cardiovascular events (MACE) (HR 1.78, 95% CI 1.44-2.23, p=< 0.001). Low transcutaneous oxygen tension (≤ 46 mmHg) was a significant predictor of major adverse cardiovascular events in patients with uncomplicated type 2 diabetes (HR 1.78; 95% CI 1.44-2.23; P<0.001).
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