Key result
Carotid intima-media thickness was significantly increased in patients with non-alcoholic (0.6 ± 0.1 mm) and alcoholic fatty liver disease (0.59 ± 0.1 mm) compared to controls (0.55 ± 0.1 mm; p<0.05).
Why the study?
Is carotid intima-media thickness increased in patients with alcoholic fatty liver disease compared to those without fatty liver?
Observational
No
Is carotid intima-media thickness increased in patients with alcoholic fatty liver disease compared to those without fatty liver?
p-value: p=<0.05
Both non-alcoholic and alcoholic fatty liver diseases are associated with increased carotid intima-media thickness, suggesting a similar increased risk for subclinical atherosclerosis.
Fatty liver links to thicker carotids irrespective of alcohol use; leaves open whether IMT improves risk stratification in AFLD.
BACKGROUND/AIMS: There are many reports of non-alcoholic fatty liver disease (NAFLD) patients with increased carotid intima-media thickness (IMT). However, there is little information about carotid IMT in alcoholic fatty liver disease (AFLD) patients. We aimed to compare the carotid IMT of NAFLD patients and AFLD patients. METHODS: The medical records of individuals who underwent carotid IMT measurement and abdominal ultrasonography between January 2006 and December 2008 at Korea University Ansan Hospital were retrospectively reviewed. The patients were divided into group A (no fatty liver without alcohol history), group B (NAFLD), group C (AFLD) and group D (no fatty liver with alcohol history). The carotid IMT results were compared across all groups. RESULTS: The mean carotid IMT was 0.55 ± 0.1 mm for group A, 0.6 ± 0.1 mm for group B, 0.59 ± 0.1 mm for group C, and 0.54 ± 0.1 mm for group D. There were significant differences between groups A and B, groups A and C, and groups C and D (p < 0.05), but there were no differences between groups B and C (p = 0.736). CONCLUSIONS: We determined that patients with fatty livers have an increased carotid IMT both in NAFLD and AFLD patients.
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Kim et al. (2011) conducted an observational in Non-alcoholic and alcoholic fatty liver disease. Non-alcoholic and alcoholic fatty liver disease vs. No fatty liver was evaluated on Carotid intima-media thickness (p=<0.05). Carotid intima-media thickness was significantly increased in patients with non-alcoholic (0.6 ± 0.1 mm) and alcoholic fatty liver disease (0.59 ± 0.1 mm) compared to controls (0.55 ± 0.1 mm; p<0.05).
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