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A commercially available nickel was utilized as an effective catalyst for the exclusive hydrogenation of nitroarenes to primary anilines in gram-scale without additional column chromatographic purification. This novel synthetic hydrogenation strategy features wide substrate scope, mild conditions and operational simplicity in aqueous media at room temperature . Further transformations resulted in the delivery of important amine-containing drugs and pharmaceutical intermediates.
Ding et al. (Mon,) studied this question.
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