Key result
Statin exposure is linked to improved cardiac mitochondrial function but increased oxidative stress in skeletal muscle.
Why the study?
Do statins induce opposite effects on mitochondria of cardiac and skeletal muscles via ROS and PGC-1 signaling?
Observational
Do statins induce opposite effects on mitochondria of cardiac and skeletal muscles via ROS and PGC-1 signaling?
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Statins exert opposite effects on cardiac and skeletal muscle mitochondria via differential ROS production and PGC-1 signaling, providing a mechanistic explanation for both their cardiovascular benefits and skeletal muscle toxicity.
Bouitbir et al. (2011) conducted an observational in Patients treated with statins and those with statin-induced muscular myopathy. Statins was evaluated on ROS production, oxidative capacities, and PGC-1 mRNA expression. Statin exposure decreased ROS production and enhanced oxidative capacities in cardiac muscle, while increasing ROS and impairing mitochondrial function in skeletal muscle.
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