This article considers optimal foldover plans for nonregular designs. By using the indicator function, we define words with fractional lengths. The extended word-length pattern is then used to select among nonregular foldover designs. Some general properties of foldover designs are obtained using the indicator function. We prove that the full-foldover plan that reverses the signs of all factors is optimal for all 12-run and 20-run orthogonal designs. The optimal foldover plans for all 16-run (regular and nonregular) orthogonal designs are constructed and tabulated for practical use. Optimal foldover plans for higher-order orthogonal designs can be constructed in a similar manner.
No takes yet. Share an insight, caveat, or question.
Li et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: