A dramatic enhancement of the stereospecificity of the title reaction was observed with trimethylphosphite-modified copper(I) alkoxide reagents. The combination of this reaction with ring-closing metathesis provides a direct approach to cis- and trans-disubstituted cyclic ethers (see scheme). A seven-step total synthesis of the natural product gaur acid highlighted the potential of this methodology. LG=leaving group.
No takes yet. Share an insight, caveat, or question.
Evans et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: