Key result
Metabolic syndrome defined by modified NCEP-ATPIII criteria was significantly associated with increased risk of carotid intima-media thickness progression (OR 4.23), but showed no predictive superiority over the Framingham Risk Score.
Why the study?
Does metabolic syndrome defined by modified NCEP-ATP III criteria predict carotid atherosclerosis in Japanese adults?
Cross-Sectional (n=615)
Does metabolic syndrome defined by modified NCEP-ATP III criteria predict carotid atherosclerosis in Japanese adults?
Odds Ratio: 4.23 (95% CI 2.94–6.09)
p-value: p=<0.0001
Modified NCEP-ATP III criteria for metabolic syndrome have an additive predictive impact on carotid atherosclerosis in Japanese adults, but are not superior to the Framingham Risk Score.
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Does not support replacing Framingham Risk Score with metabolic syndrome criteria for carotid risk assessment; extends observational data in Japanese adults but leaves predictive superiority open.
Teramura et al. (2007) conducted a cross-sectional in Metabolic syndrome and carotid atherosclerosis (n=615). Metabolic syndrome (modified NCEP-ATPIII criteria) vs. Without metabolic syndrome was evaluated on Carotid intima-media thickness (IMT) progressor (≥0.874 mm) (OR 4.23, 95% CI 2.94-6.09, p=<0.0001). Metabolic syndrome defined by modified NCEP-ATPIII criteria was significantly associated with increased risk of carotid intima-media thickness progression (OR 4.23), but showed no predictive superiority over the Framingham Risk Score.
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