Key result
Higher cardiometabolic risk score is linked to ~20% higher post-MI diabetes risk per point.
Why the study?
AMI and T2DM share common risk factors, prompting an evaluation of the long-term incidence and predictors of new-onset T2DM among post-AMI adults.
What is the incidence and what are the predictors of new-onset type 2 diabetes mellitus (NODM) among adult acute myocardial infarction survivors?
Cohort (n=5,147)
No
What is the incidence and what are the predictors of new-onset type 2 diabetes mellitus (NODM) among adult acute myocardial infarction survivors?
Following acute myocardial infarction, patients face a high cumulative risk of developing new-onset type 2 diabetes, highlighting the critical need for aggressive metabolic screening and risk factor management during secondary prevention.
Answers are grounded in this paper and cite their sources.
Risk stratification may identify post-MI patients prone to new-onset diabetes; hypothesis-generating and requires prospective validation before adoption.
Acute myocardial infarction (AMI) and type 2 diabetes mellitus (T2DM) share common risk factors. To evaluate the long-term incidence and predictors of new-onset T2DM (NODM) among post-AMI adults, we conducted a retrospective analysis of AMI survivors hospitalized between 2002 and 2017. Eligible patients were followed for up to 16 years to identify NODM, stratified by demographic and clinical characteristics. Among 5147 individuals (74.2% males, mean age 64.6 ± 14.9 years) without pre-existing T2DM, 23.4% developed NODM (cumulative incidence: 0.541). Key risk factors included an age of 50–60 years, a minority ethnicity (Arabs), smoking, metabolic syndrome (MetS), hemoglobin A1C (HbA1C) ≥ 5.7%, and cardiovascular comorbidities. A total score (TS), integrating these factors, revealed a linear association with the NODM risk: each 1-point increase corresponded to a 1.2-fold rise (95% CI 1.191–1.276, p < 0.001). HbA1C ≥ 6% on the “Pre-DM sub-scale” conferred a 2.8-fold risk (p < 0.001), while other risk factors also independently predicted NODM. In conclusion, post-AMI patients with multiple cardiovascular risk factors, particularly middle-aged individuals, Arab individuals, and those with HbA1C ≥ 6% or MetS, are at a heightened risk of NODM. Early identification and targeted interventions may mitigate this risk.
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Yakubov et al. (2025) conducted a cohort in Acute Myocardial Infarction (AMI) without pre-existing type 2 diabetes (n=5,147). Cardiometabolic risk factor burden vs. Lower risk factor burden was evaluated on New-onset type 2 diabetes mellitus (NODM) (HR 1.2, 95% CI 1.191-1.276, p=<0.001). Higher burden of demographic and cardiometabolic risk factors increased the risk of new-onset diabetes following myocardial infarction, with a 1.2-fold risk increase per 1-point rise in total risk score.
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