PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
July 22, 2026Tissue Barriers

Modeling tonsil organoids for studying mucosal immune responses to SARS-CoV-2 vaccination

View Full Paper
Ask AI
Bookmark
Share

Authors

YGYang GaoWWWan WangYWYuxing Wang

Discussion

Loading...

Member takes

Overview

Randomized trial models mucosal immune responses to SARS-CoV-2 vaccination in tonsil organoids, suggesting a new path for vaccine research.

Key Points

  • The aim is to create a human in vitro system using tonsil organoids to study mucosal immune responses to a SARS-CoV-2 vaccine.
  • Established a human tonsil organoid platform
  • Stimulated with the AdC68-19S SARS-CoV-2 vaccine candidate
  • Analyzed immune responses using flow cytometry and enzyme-linked assays.
  • AdC68-19S immunization produced organized germinal centers in tonsil organoids with specific compartments
  • Generated antigen-specific IgG and IgA with neutralizing capacity against SARS-CoV-2 pseudovirus
  • Expanded key immune cell populations including GC B cells and plasma cells.

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/6a605cf44163e025518d72fbhttps://doi.org/10.1080/21688370.2026.2700690
View Full Paper
Ask AI
Bookmark
Share