Combination-Based Biofunctional Coatings for Veterinary Biofilm-Associated Infections

Biofilm-associated infections present a significant but insufficiently acknowledged problem in veterinary medicine because they result in persistent infections that lead to unsuccessful treatments and drive the growth of antimicrobial resistance throughout animal healthcare systems. The extracellular matrix of biofilms together with their resistance mechanisms make traditional antimicrobial methods ineffective against these structures. The development of combination-based biomaterial coatings represents an effective solution for biofilm control since these coatings combine different antimicrobial capabilities into one surface treatment. This review offers an in-depth evaluation of veterinary-focused combination-based coating systems which scientists developed to create solutions for catheterization, orthopedic, dental implant procedures, wound treatment and aquaculture infrastructure. This review also examines various coating methods to determine their effectiveness in creating surfaces that optimize antimicrobial delivery. However, the development of veterinary medical solutions faces major obstacles because the technology needs to overcome some key issues, which include maintaining stability through time, protecting animal health, preventing environmental harm and meeting regulatory standards. Overall, the use of multifunctional biomaterial functional coatings provides veterinary medicine with a revolutionary method to handle biofilm-related infections in animals, which decreases the need for antibiotics while improving infection control according to One Health principles.