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July 22, 2026BiomoleculesOpen Access

Narrative Review of the Pathophysiology of Post-Infectious Bronchiolitis Obliterans

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Authors

AZAlessandro ZagoCCC CocchiMMMassimo Maschio

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Overview

Narrative review highlights the mechanisms and treatments for post-infectious bronchiolitis obliterans, suggesting improvements in therapy.

Key Points

  • This review explores the complex pathophysiological mechanisms of post-infectious bronchiolitis obliterans (PIBO) and its implications for treatment.
  • Narrative review of existing literature on PIBO
  • Analysis of the role of pathogens, immune response, and genetic factors
  • Discussion of histological changes in PIBO progression
  • PIBO is primarily associated with adenovirus and characterized by irreversible airflow limitation.
  • Key mechanisms include severe epithelial injury, persistent neutrophilic inflammation, and activation of the TGF-β/CTGF pathway.
  • The review suggests targeting inflammation early and fibrotic remodeling later for more effective therapeutic strategies.

Cite This Study

Zago et al. (2026) studied this question.

synapsesocial.com/papers/6a605e1c4163e025518d7efbhttps://doi.org/10.3390/biom16071061
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