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Investigates the effects of pneumatic injury on swimming activity in larval zebrafish, indicating a new standard for TBI research.
Zebrafish are an emerging vertebrate model for traumatic brain injury (TBI) research, but current larval injury paradigms, especially weight-drop methods, can be difficult to standardize. Here, we describe the Zebrafish Pneumatic Injury Device (ZePID), a compact pneumatic piston system that delivers controlled, reproducible pressure pulses to induce TBI in larval zebrafish. ZePID showed a strong linear relationship between input and delivered pressure and reduced variability relative to weight-drop approaches. In 6-days postfertilization larvae, a 150 psi injury increased maximum swimming speed and total distance traveled, consistent with seizure-like hyperactivity after TBI.
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Wang et al. (2026) studied this question.
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