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Uncovers aging-related genes and pathways in liver transplant recipients, suggesting long-term survival is linked to immune epigenetic changes.
Biological aging may influence long-term outcomes following liver transplantation (LT), yet longitudinal epigenetic changes in transplant recipients remain poorly characterized. Peripheral blood mononuclear cells (PBMCs) from LT recipients were analyzed using Infinium Methylation EPIC v2.0 arrays at transplantation (T0), five years (T5), and ten years (T10) post-transplant. Differentially methylated regions (DMRs) and epigenetic age acceleration were evaluated. The largest epigenetic changes occurred between five and ten years post-transplant, with 211 DMRs enriched in immune-related pathways. However, epigenetic clock analyses showed no significant differences in biological age acceleration. Long-term LT survival is associated with immune-related epigenetic remodeling rather than global biological aging acceleration.
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Baciu et al. (2026) studied this question.
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