Metabolic Syndrome and In-Hospital Mortality in Sepsis: A Multicenter Cohort Study Revealing a Severity-Dependent Survival Advantage Driven by Overweight and Hyperlipidemia

Yining Zhang; G H Liu; Xianxian Yu; Zhaoming Shang; Hui Liu; Huailong Shang; W Sun; Can Li; Xiao Cui; Jiameng Chen; Junwei Qian; W Y Zhou; Mao E; Mingquan Chen; Chengjin Gao

doi:10.1097/shk.0000000000002910

July 20, 2026Shock

Metabolic Syndrome and In-Hospital Mortality in Sepsis: A Multicenter Cohort Study Revealing a Severity-Dependent Survival Advantage Driven by Overweight and Hyperlipidemia

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Key Points

This study aims to explore the link between metabolic syndrome and in-hospital mortality among sepsis patients, analyzing the impact of disease severity and specific metabolic components.
Multicenter retrospective cohort study involving 2,973 adult sepsis patients from three hospitals in China.
In-hospital mortality was assessed using multivariable Cox regression with interaction analyses and Kaplan-Meier survival analysis.
Metabolic syndrome was defined per the Chinese Diabetes Society criteria.
Patients with metabolic syndrome had a higher in-hospital survival rate (78.4%) compared to those without (72.8%), p=0.001.
Metabolic syndrome remained linked to lower in-hospital mortality after adjusting for confounders.
A significant interaction between metabolic syndrome and SOFA-defined severity strata indicated the survival benefit was mainly in mild-to-moderate sepsis, driven by overweight and hyperlipidemia.

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Implication

Multicenter cohort study evaluates the death risk from sepsis in patients with metabolic syndrome, suggesting a survival benefit based on severity levels.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a605e7c4163e025518d84a8 https://doi.org/10.1097/shk.0000000000002910

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Metabolic Syndrome and In-Hospital Mortality in Sepsis: A Multicenter Cohort Study Revealing a Severity-Dependent Survival Advantage Driven by Overweight and Hyperlipidemia

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Cite This Study

Metabolic Syndrome and In-Hospital Mortality in Sepsis: A Multicenter Cohort Study Revealing a Severity-Dependent Survival Advantage Driven by Overweight and Hyperlipidemia

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