Key result
The P2X7 receptor plays a critical role in the onset, progression, and resolution of cardiovascular diseases by modulating the NLRP3 inflammasome and secretion of pro-inflammatory factors.
Why the study?
Recent studies demonstrate that the P2X7 receptor modulates NLRP3 inflammasome assembly and worsens cardiac phenotypes, prompting discussion of its molecular role in cardiovascular diseases and putative therapies.
The P2X7 receptor plays a critical role in cardiovascular disease pathophysiology via inflammatory pathways, presenting a potential target for future therapies.
Answers are grounded in this paper and cite their sources.
P2X7 antagonists merit preclinical validation in cardiovascular disease; leaves open whether modulation improves clinical outcomes.
The P2X7 receptor is a ligand-gated purinergic receptor activated by extracellular ATP. The receptor is highly expressed in immune cells and in the brain, and, upon activation, the P2X7 receptor allows a cation flux, leading to the distinct activation of intracellular signalling pathways as the secretion of pro-inflammatory cytokines, and modulation of cell survival. Through these molecular mechanisms, P2X7 is known to play important roles in physiology and pathophysiology of a wide spectrum of diseases, including cancer, inflammatory diseases, neurological, respiratory and more recently cardiovascular diseases. Recent studies demonstrated that the P2X7 could modulate the assembly of the NLRP3 inflammasome, leading to the secretion of pro-inflammatory factors and worsen the cardiac disease phenotypes. This review discusses the critical molecular function of P2X7 in the modulation of the onset, progression and resolution of cardiovascular diseases and analyses the putative future use of P2X7-based therapies that modulate the IL-1β secretion arm and direct P2X7 antagonists.
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Camila Guerra Martinez (2019) conducted a review in Cardiovascular diseases. P2X7 receptor modulation was evaluated. The P2X7 receptor plays a critical role in the onset, progression, and resolution of cardiovascular diseases by modulating the NLRP3 inflammasome and secretion of pro-inflammatory factors.
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