Introduction Activation of caspases Small molecule inhibitors of caspase activity and activation Role of caspases in disease Challenges facing the development of caspase therapeutics Role of caspases in other aspects of cell death Role of caspases in non‐apoptotic and non‐inflammatory processes The future of caspase therapeutics Abstract The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis‐related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase‐associated disorders while focusing on caspase‐1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed.
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Howley et al. (2008) studied this question.
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