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Demonstrates the link between vibrational dynamics and drug resistance in HIV-1 protease, implying new insights for treatment.
at 300 K, or 25%, to the free energy of darunavir binding. As HIV-1 protease drug resistance remains a concern, our results open a new avenue to help establish a direct quantitative link between protein vibrational dynamics and drug resistance.
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Kneller et al. (2022) studied this question.
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