Why the study?
Little is known about the mechanisms causing supply/demand imbalance in T2MI or how they are modulated by CAD, which remains underrecognized and undertreated despite its prognostic value.
Systematic Review
Underlying CAD in T2MI is a critical driver of poor outcomes that remains severely undertreated, emphasizing the need for targeted risk stratification and dedicated clinical trials.
Underlying coronary artery disease (CAD) is increasingly considered to be a key issue in the pathophysiology of type 2 myocardial infarction (T2MI). In T2MI, which is attributable to a mismatch between oxygen supply/demand, CAD is common and appears to be more severe than in type 1 myocardial infarction (T1MI). Little is known about the heterogeneous mechanisms that cause supply/demand imbalance and non-coronary triggers leading to myocardial ischemia or about how they are potentially modulated by the presence and severity of CAD. CAD seems to be underrecognized and undertreated in T2MI, even though previous studies have demonstrated both the short and long-term prognostic value of CAD in T2MI. In this literature review, we attempt to address the prevalence and severity of CAD, challenges in the discrimination between T2MI and T1MI in the presence of CAD, and the prognostic value of CAD among patients with T2MI.
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Yao et al. (2023) conducted a systematic review in Type 2 Myocardial Infarction. Coronary artery disease vs. Absence of coronary artery disease or Type 1 Myocardial Infarction was evaluated.
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