Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

Daniel F. Dwyer; José Ordovás-Montañés; Samuel J. Allon; Kathleen M. Buchheit; Marko Vukovic; Tahereh Derakhshan; Chunli Feng; Juying Lai; Travis K. Hughes; Sarah K. Nyquist; Matthew P. Giannetti; Bonnie Berger; Neil Bhattacharyya; Rachel E. Roditi; Howard R. Katz; Martijn C. Nawijn; Marijn Berg; Maarten van den Berge; Tanya M. Laidlaw; Alex K. Shalek; Nora A. Barrett; Joshua A. Boyce

doi:10.1126/sciimmunol.abb7221

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Abstract

in nasal polyps and skin. These results indicate that MCs display distinct inflammation-associated effector programs and suggest that in situ MC proliferation is a major component of MC hyperplasia in human T2 inflammation.

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Dwyer et al. (2021) studied this question.

synapsesocial.com/papers/6a6140046b7099fe363f3daf https://doi.org/10.1126/sciimmunol.abb7221

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Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

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Abstract

Discussion

Cite This Study

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation

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Abstract

Discussion

Cite This Study

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