Key result
Multimodality imaging and Raman spectroscopy of an excised unicuspid aortic valve revealed a slit-shaped unicommissural structure with severe calcification predominantly composed of calcium hydroxyapatite.
Why the study?
Unicuspid aortic valve is an extremely rare congenital cardiac malformation that leads to aortic stenosis, aortic regurgitation, or both.
Case Report (n=1)
No
Multimodality imaging and Raman spectroscopy revealed that calcium hydroxyapatite and type-B carbonate apatite are the predominant calcification components in a rare case of unicuspid aortic valve stenosis.
Single-case analysis offers no clinical practice change; leaves open mechanistic research on hydroxyapatite in unicuspid valves.
Unicuspid aortic valve (UAV) is an extremely rare form of congenital cardiac malformation, leading to aortic stenosis (AS), aortic regurgitation (AR), or both. We report the case of a 55-year-old man with unicommissural UAV associated with severe AS and mild AR using different multimodality imaging approaches. The excised UAV isolated after aortic valve replacement exhibited an eccentric "teardrop" opening with a slit-shaped unicommissural structure. Raman spectroscopic results indicated that 3 unevenly distributed components were deposited on the surface of the UAV, in which calcium hydroxyapatite and type-B carbonate apatite were the predominate components deposited on the surface, leading to severe AS formation.
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Chang et al. (2019) conducted a case report in Unicuspid aortic valve stenosis (n=1). Multimodality imaging, X-ray radiography, and Raman analysis was evaluated on Morphological and compositional assessment of the excised unicuspid aortic valve. Multimodality imaging and Raman spectroscopy of an excised unicuspid aortic valve revealed a slit-shaped unicommissural structure with severe calcification predominantly composed of calcium hydroxyapatite.
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